EPITARGET partner Christophe Bernard from Aix Marseille University recently published a paper with the title "Controlling Epileptiform Activity with Organic Electronic Ion Pumps" in the journal Advanced Materials.

In this paper, the authors demonstrate an organic electronic ion pump that can deliver pure molecules directly in the regions of interest to control epileptic activity, without affecting the function of neighbouring regions, thus solving the following problems: Many potentially potent anti-epileptic drugs failed in the clinic because: i) they could not reach the brain (i.e. not passing the brain blood barrier); ii) they had deleterious side effects, affecting the function of “healthy” regions; iii) they were toxic in the periphery (e.g. in the liver). The device is minimally invasive and biocompatible, which opens the way to deliver already designed potent drugs where and when they are needed.

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